Nitroglcerin for anal fissure

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Nitroglycerin Ointment for Anal Fissures: Effective Treatment or Just a Headache?

Topical Nitroglycerin in the Management of Anal Fissure: An Explosive Outcome! - PubMed

Purpose: Topical nitrates have been shown to cause nitric oxide-mediated relaxation of the internal anal sphincter. Previous reports have suggested initial efficacy in the treatment of anal fissures. The aim of this study was to assess the longer-term usefulness of this treatment. Methods: Thirty-three patients with an anal fissure were treated with topical 0. Patients were followed up by office visits and telephone calls until symptoms were completely resolved or treatment was noted to be ineffective or intolerable. Results: Thirty-three patients were treated, 16 with acute fissures, and 17 with chronic fissures. Conclusions: Topical nitroglycerin was only effective in approximately one-half of patients with an anal fissure.

Understand

Application of a 0. You rub a pea-sized dot of cream on the fissure twice a day. It is a good idea to either wear gloves when applying the nitroglycerin cream or wash your hands right after. The skin on your fingers can absorb the medicine and increase your chance of side effects. An increase in muscle tension, also called resting pressure, in the internal anal sphincter can lead to fissures.
Anal sphincter spasm is a common finding in patients with anal fissure disease. It is postulated that spasm impedes mucosal blood flow and impairs healing. Topical nitroglycerin NTG , a nitric oxide donor compound, has been shown to cause relaxation of the anal sphincter and may have treatment efficacy in the management of anal fissure. The purpose of this study was to assess the usefulness of NTG for anal fissure. We performed a retrospective review of patients with anal fissure treated with various concentrations of topical NTG ointments over an month period ending July
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